Osteocyte TSC1 promotes sclerostin secretion to restrain osteogenesis in mice

Osteocytes secrete the glycoprotein sclerostin to inhibit bone formation by osteoblasts, but how sclerostin production is regulated in osteocytes remains unclear. Here, we show that tuberous sclerosis complex 1 (TSC1) in osteocytes promotes sclerostin secretion through inhibition of mechanistic targ...

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Detalles Bibliográficos
Autores principales: Liu, Wen, Wang, Zhenyu, Yang, Jun, Wang, Yongkui, Li, Kai, Huang, Bin, Yan, Bo, Wang, Ting, Li, Mangmang, Zou, Zhipeng, Yang, Jian, Xiao, Guozhi, Cui, Zhong-Kai, Liu, Anling, Bai, Xiaochun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544986/
https://www.ncbi.nlm.nih.gov/pubmed/31088250
http://dx.doi.org/10.1098/rsob.180262

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544986/
https://www.ncbi.nlm.nih.gov/pubmed/31088250
http://dx.doi.org/10.1098/rsob.180262

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