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Clinical biomarker discovery by SWATH-MS based label-free quantitative proteomics: impact of criteria for identification of differentiators and data normalization method

BACKGROUND: SWATH-MS has emerged as the strategy of choice for biomarker discovery due to the proteome coverage achieved in acquisition and provision to re-interrogate the data. However, in quantitative analysis using SWATH, each sample from the comparison group is run individually in mass spectrome...

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Detalles Bibliográficos
Autores principales:	Narasimhan, Mythreyi, Kannan, Sadhana, Chawade, Aakash, Bhattacharjee, Atanu, Govekar, Rukmini
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545036/ https://www.ncbi.nlm.nih.gov/pubmed/31151397 http://dx.doi.org/10.1186/s12967-019-1937-9

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