Induction of the cell survival kinase Sgk1: A possible novel mechanism for α-phenyl-N-tert-butyl nitrone in experimental stroke

Nitrones (e.g. α-phenyl-N-tert-butyl nitrone; PBN) are cerebroprotective in experimental stroke. Free radical trapping is their proposed mechanism. As PBN has low radical trapping potency, we tested Sgk1 induction as another possible mechanism. PBN was injected (100 mg/kg, i.p.) into adult male rats...

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Detalles Bibliográficos
Autores principales: McCaig, Catherine, Ataliotis, Paris, Shtaya, Anan, Omar, Ayan S, Green, A Richard, Kind, Clive N, Pereira, Anthony C, Naray-Fejes-Toth, Aniko, Fejes-Toth, Geza, Yáñez-Muñoz, Rafael J, Murray, James T, Hainsworth, Atticus H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545623/
https://www.ncbi.nlm.nih.gov/pubmed/29260627
http://dx.doi.org/10.1177/0271678X17746980

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545623/
https://www.ncbi.nlm.nih.gov/pubmed/29260627
http://dx.doi.org/10.1177/0271678X17746980

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