Downregulation of TREM-like transcript-1 and collagen receptor α2 subunit, two novel RUNX1-targets, contributes to platelet dysfunction in familial platelet disorder with predisposition to acute myelogenous leukemia

Germline RUNX1 mutations lead to thrombocytopenia and platelet dysfunction in familial platelet disorder with predisposition to acute myelogenous leukemia (AML). Multiple aspects of platelet function are impaired in these patients, associated with altered expression of genes regulated by RUNX1. We a...

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Detalles Bibliográficos
Autores principales: Glembotsky, Ana C., Sliwa, Dominika, Bluteau, Dominique, Balayn, Nathalie, Marin Oyarzún, Cecilia P., Raimbault, Anna, Bordas, Marie, Droin, Nathalie, Pirozhkova, Iryna, Washington, Valance, Goette, Nora P., Marta, Rosana F., Favier, Rémi, Raslova, Hana, Heller, Paula G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545826/
https://www.ncbi.nlm.nih.gov/pubmed/30545930
http://dx.doi.org/10.3324/haematol.2018.188904

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545826/
https://www.ncbi.nlm.nih.gov/pubmed/30545930
http://dx.doi.org/10.3324/haematol.2018.188904

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