Transient Kinetic Analysis of SWR1C-Catalyzed H2A.Z Deposition Unravels the Impact of Nucleosome Dynamics and the Asymmetry of Histone Exchange

The SWR1C chromatin remodeling enzyme catalyzes ATP-dependent replacement of nucleosomal H2A with the H2A.Z variant, regulating key DNA-mediated processes such as transcription and DNA repair. Here, we investigate the transient kinetic mechanism of the histone exchange reaction, employing ensemble F...

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Detalles Bibliográficos
Autores principales: Singh, Raushan K., Fan, Jiayl, Gioacchini, Nathan, Watanabe, Shinya, Bilsel, Osman, Peterson, Craig L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545893/
https://www.ncbi.nlm.nih.gov/pubmed/30970243
http://dx.doi.org/10.1016/j.celrep.2019.03.035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545893/
https://www.ncbi.nlm.nih.gov/pubmed/30970243
http://dx.doi.org/10.1016/j.celrep.2019.03.035

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