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IL-1β-Mediated Activation of Adipose-Derived Mesenchymal Stromal Cells Results in PMN Reallocation and Enhanced Phagocytosis: A Possible Mechanism for the Reduction of Osteoarthritis Pathology

Background: Injection of adipose-derived mesenchymal stromal cells (ASCs) into murine knee joints after induction of inflammatory collagenase-induced osteoarthritis (CiOA) reduces development of joint pathology. This protection is only achieved when ASCs are applied in early CiOA, which is character...

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Detalles Bibliográficos
Autores principales: van Dalen, Stephanie C. M., Blom, Arjen B., Walgreen, Birgitte, Slöetjes, Annet W., Helsen, Monique M. A., Geven, Edwin J. W., ter Huurne, Menno, Vogl, Thomas, Roth, Johannes, van de Loo, Fons A. J., Koenders, Marije I., Casteilla, Louis, van der Kraan, Peter M., van den Bosch, Martijn H. J., van Lent, Peter L. E. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545928/
https://www.ncbi.nlm.nih.gov/pubmed/31191517
http://dx.doi.org/10.3389/fimmu.2019.01075