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Ccr4–Not maintains genomic integrity by controlling the ubiquitylation and degradation of arrested RNAPII
The Ccr4–Not complex regulates essentially every aspect of gene expression, from mRNA synthesis to protein destruction. The Not4 subunit of the complex contains an E3 RING domain and targets proteins for ubiquitin-dependent proteolysis. Ccr4–Not associates with elongating RNA polymerase II (RNAPII),...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546055/ https://www.ncbi.nlm.nih.gov/pubmed/30948432 http://dx.doi.org/10.1101/gad.322453.118 |