Nr4a transcription factors limit CAR T cell function in solid tumors

T cells expressing chimeric antigen receptors (CAR) targeting human CD19 (huCD19) have exhibited impressive clinical efficacy against B cell malignancies(1,2). CAR-T cells have been less effective against solid tumors(3–5), in part because they enter a hyporesponsive (“exhausted” or “dysfunctional”)...

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Detalles Bibliográficos
Autores principales: Chen, Joyce, López-Moyado, Isaac F., Seo, Hyungseok, Lio, Chan-Wang J., Hempleman, Laura J., Sekiya, Takashi, Yoshimura, Akihiko, Scott-Browne, James P., Rao, Anjana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546093/
https://www.ncbi.nlm.nih.gov/pubmed/30814732
http://dx.doi.org/10.1038/s41586-019-0985-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546093/
https://www.ncbi.nlm.nih.gov/pubmed/30814732
http://dx.doi.org/10.1038/s41586-019-0985-x

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