Heritability in genetic heart disease: the role of genetic background

BACKGROUND: Mutations in genes encoding ion channels or sarcomeric proteins are an important cause of hereditary cardiac disease. However, the severity of the resultant disease varies considerably even among those with an identical mutation. Such clinical variation is often thought to be explained l...

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Detalles Bibliográficos
Autores principales: Jansweijer, Joeri A, van Spaendonck-Zwarts, Karin Y, Tanck, Michael W T, van Tintelen, J Peter, Christiaans, Imke, van der Smagt, Jasper J, Vermeer, Alexa M C, Bos, J Martijn, Moss, Arthur J, Swan, Heikki, Priori, Sylvia G, Rydberg, Annika, Tfelt-Hansen, Jacob, Ackerman, Michael J, Olivotto, Iacopo, Charron, Philippe, Gimeno, Juan R, van den Berg, Maarten P, Wilde, Arthur AM, Pinto, Yigal M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Basic and Translational Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546190/
https://www.ncbi.nlm.nih.gov/pubmed/31245010
http://dx.doi.org/10.1136/openhrt-2018-000929

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546190/
https://www.ncbi.nlm.nih.gov/pubmed/31245010
http://dx.doi.org/10.1136/openhrt-2018-000929

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