Dimethyl fumarate dosing in humans increases frataxin expression: A potential therapy for Friedreich’s Ataxia

Friedreich’s Ataxia (FA) is an inherited neurodegenerative disorder resulting from decreased expression of the mitochondrial protein frataxin, for which there is no approved therapy. High throughput screening of clinically used drugs identified Dimethyl fumarate (DMF) as protective in FA patient cel...

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Detalles Bibliográficos
Autores principales: Jasoliya, Mittal, Sacca, Francesco, Sahdeo, Sunil, Chedin, Frederic, Pane, Chiara, Brescia Morra, Vincenzo, Filla, Alessandro, Pook, Mark, Cortopassi, Gino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546270/
https://www.ncbi.nlm.nih.gov/pubmed/31158268
http://dx.doi.org/10.1371/journal.pone.0217776

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546270/
https://www.ncbi.nlm.nih.gov/pubmed/31158268
http://dx.doi.org/10.1371/journal.pone.0217776

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