Extracellular microRNAs exhibit sequence-dependent stability and cellular release kinetics

Multiple studies have described extracellular microRNAs (ex-miRNAs) as being remarkably stable despite the hostile extracellular environment, when stored at 4ºC or lower. Here we show that many ex-miRNAs are rapidly degraded when incubated at 37ºC in the presence of serum (thereby simulating physiol...

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Detalles Bibliográficos
Autores principales: Coenen-Stass, Anna M. L., Pauwels, Marie J., Hanson, Britt, Martin Perez, Carla, Conceição, Mariana, Wood, Matthew J. A., Mäger, Imre, Roberts, Thomas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546368/
https://www.ncbi.nlm.nih.gov/pubmed/30836828
http://dx.doi.org/10.1080/15476286.2019.1582956

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546368/
https://www.ncbi.nlm.nih.gov/pubmed/30836828
http://dx.doi.org/10.1080/15476286.2019.1582956

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