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Extracellular microRNAs exhibit sequence-dependent stability and cellular release kinetics
Multiple studies have described extracellular microRNAs (ex-miRNAs) as being remarkably stable despite the hostile extracellular environment, when stored at 4ºC or lower. Here we show that many ex-miRNAs are rapidly degraded when incubated at 37ºC in the presence of serum (thereby simulating physiol...
Autores principales: | Coenen-Stass, Anna M. L., Pauwels, Marie J., Hanson, Britt, Martin Perez, Carla, Conceição, Mariana, Wood, Matthew J. A., Mäger, Imre, Roberts, Thomas C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546368/ https://www.ncbi.nlm.nih.gov/pubmed/30836828 http://dx.doi.org/10.1080/15476286.2019.1582956 |
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