Boosting AgoshRNA activity by optimized 5’-terminal nucleotide selection

RNA interference (RNAi) can be triggered by synthetic small interfering RNAs (siRNAs) or transgene-expressed short hairpin RNAs (shRNAs). Recent evidence indicates that shRNA molecules, with a relatively short stem and small loop, are processed by Argonaute 2 protein (Ago2). We named these molecules...

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Detalles Bibliográficos
Autores principales: Gao, Zongliang, Berkhout, Ben, Herrera-Carrillo, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546398/
https://www.ncbi.nlm.nih.gov/pubmed/30991896
http://dx.doi.org/10.1080/15476286.2019.1599259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546398/
https://www.ncbi.nlm.nih.gov/pubmed/30991896
http://dx.doi.org/10.1080/15476286.2019.1599259

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