Defining the seed sequence of the Cas12b CRISPR-Cas effector complex

Target binding by CRISPR-Cas ribonucleoprotein effectors is initiated by the recognition of double-stranded PAM motifs by the Cas protein moiety followed by destabilization, localized melting, and interrogation of the target by the guide part of CRISPR RNA moiety. The latter process depends on seed...

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Detalles Bibliográficos
Autores principales: Jain, Ishita, Minakhin, Leonid, Mekler, Vladimir, Sitnik, Vasily, Rubanova, Natalia, Severinov, Konstantin, Semenova, Ekaterina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546406/
https://www.ncbi.nlm.nih.gov/pubmed/30022698
http://dx.doi.org/10.1080/15476286.2018.1495492

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546406/
https://www.ncbi.nlm.nih.gov/pubmed/30022698
http://dx.doi.org/10.1080/15476286.2018.1495492

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