Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase

Bacterial ClpB and yeast Hsp104 are homologous Hsp100 protein disaggregases that serve critical functions in proteostasis by solubilizing protein aggregates. Two AAA+ nucleotide binding domains (NBDs) power polypeptide translocation through a central channel comprised of a hexameric spiral of protom...

Descripción completa

Detalles Bibliográficos
Autores principales: Rizo, Alexandrea N., Lin, JiaBei, Gates, Stephanie N., Tse, Eric, Bart, Stephen M., Castellano, Laura M., DiMaio, Frank, Shorter, James, Southworth, Daniel R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546751/
https://www.ncbi.nlm.nih.gov/pubmed/31160557
http://dx.doi.org/10.1038/s41467-019-10150-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546751/
https://www.ncbi.nlm.nih.gov/pubmed/31160557
http://dx.doi.org/10.1038/s41467-019-10150-y

Ejemplares similares