Enzyme-mediated depletion of l-cyst(e)ine synergizes with thioredoxin reductase inhibition for suppression of pancreatic tumor growth

Perturbing redox homeostasis potentially constitutes a selective cancer-killing strategy. An engineered human enzyme, cyst(e)inase that degrades extracellular cysteine (l-Cys) and cystine (CSSC) leading to depletion of intracellular l-Cys and glutathione (GSH) was evaluated for its effects on pancre...

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Detalles Bibliográficos
Autores principales: Kshattry, Sabin, Saha, Achinto, Gries, Paul, Tiziani, Stefano, Stone, Everett, Georgiou, George, DiGiovanni, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546752/
https://www.ncbi.nlm.nih.gov/pubmed/31231686
http://dx.doi.org/10.1038/s41698-019-0088-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546752/
https://www.ncbi.nlm.nih.gov/pubmed/31231686
http://dx.doi.org/10.1038/s41698-019-0088-z

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