Tau binding protein CAPON induces tau aggregation and neurodegeneration

To understand the molecular processes that link Aβ amyloidosis, tauopathy and neurodegeneration, we screened for tau-interacting proteins by immunoprecipitation/LC-MS. We identified the carboxy-terminal PDZ ligand of nNOS (CAPON) as a novel tau-binding protein. CAPON is an adaptor protein of neurona...

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Detalles Bibliográficos
Autores principales: Hashimoto, Shoko, Matsuba, Yukio, Kamano, Naoko, Mihira, Naomi, Sahara, Naruhiko, Takano, Jiro, Muramatsu, Shin-ichi, Saido, Takaomi C., Saito, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546774/
https://www.ncbi.nlm.nih.gov/pubmed/31160584
http://dx.doi.org/10.1038/s41467-019-10278-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546774/
https://www.ncbi.nlm.nih.gov/pubmed/31160584
http://dx.doi.org/10.1038/s41467-019-10278-x

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