Feed-forward regulation adaptively evolves via dynamics rather than topology when there is intrinsic noise

In transcriptional regulatory networks (TRNs), a canonical 3-node feed-forward loop (FFL) is hypothesized to evolve to filter out short spurious signals. We test this adaptive hypothesis against a novel null evolutionary model. Our mutational model captures the intrinsically high prevalence of weak...

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Detalles Bibliográficos
Autores principales: Xiong, Kun, Lancaster, Alex K., Siegal, Mark L., Masel, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546794/
https://www.ncbi.nlm.nih.gov/pubmed/31160574
http://dx.doi.org/10.1038/s41467-019-10388-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546794/
https://www.ncbi.nlm.nih.gov/pubmed/31160574
http://dx.doi.org/10.1038/s41467-019-10388-6

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