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Feed-forward regulation adaptively evolves via dynamics rather than topology when there is intrinsic noise
In transcriptional regulatory networks (TRNs), a canonical 3-node feed-forward loop (FFL) is hypothesized to evolve to filter out short spurious signals. We test this adaptive hypothesis against a novel null evolutionary model. Our mutational model captures the intrinsically high prevalence of weak...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546794/ https://www.ncbi.nlm.nih.gov/pubmed/31160574 http://dx.doi.org/10.1038/s41467-019-10388-6 |