Transcriptional Repression of CYP3A4 by Increased miR-200a-3p and miR-150-5p Promotes Steatosis in vitro

Hepatic cytochrome P450 enzyme activities correlate with non-alcoholic fatty liver disease (NAFLD) and hepatic steatosis. The decreased activity of CYP3A4, an important drug-metabolizing enzyme, is associated with the progression of NAFLD. CYP3A4 is predicted as a target gene of miR-200a-3p and miR-...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Zhijun, Wang, Mengyao, Liu, Li, Peng, Jinfu, Guo, Chengxian, Chen, Xiaoping, Huang, Lu, Tan, Jieqiong, Yang, Guoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546834/
https://www.ncbi.nlm.nih.gov/pubmed/31191607
http://dx.doi.org/10.3389/fgene.2019.00484

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546834/
https://www.ncbi.nlm.nih.gov/pubmed/31191607
http://dx.doi.org/10.3389/fgene.2019.00484

Ejemplares similares