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Transcriptional Repression of CYP3A4 by Increased miR-200a-3p and miR-150-5p Promotes Steatosis in vitro

Hepatic cytochrome P450 enzyme activities correlate with non-alcoholic fatty liver disease (NAFLD) and hepatic steatosis. The decreased activity of CYP3A4, an important drug-metabolizing enzyme, is associated with the progression of NAFLD. CYP3A4 is predicted as a target gene of miR-200a-3p and miR-...

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Detalles Bibliográficos
Autores principales:	Huang, Zhijun, Wang, Mengyao, Liu, Li, Peng, Jinfu, Guo, Chengxian, Chen, Xiaoping, Huang, Lu, Tan, Jieqiong, Yang, Guoping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546834/ https://www.ncbi.nlm.nih.gov/pubmed/31191607 http://dx.doi.org/10.3389/fgene.2019.00484

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