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Irisin Is Controlled by Farnesoid X Receptor and Regulates Cholesterol Homeostasis
OBJECTIVE: The aim of this study was to investigate whether the nuclear receptor farnesoid X receptor (FXR) could regulate FNDC5/Irisin expression and the role of Irisin in hyperlipidemia and atherosclerosis in ApoE-/- mice. METHODS AND RESULTS: We treated primary human hepatocytes, HepG2 cells, and...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546903/ https://www.ncbi.nlm.nih.gov/pubmed/31191305 http://dx.doi.org/10.3389/fphar.2019.00548 |