Single-stranded regions modulate conformational dynamics and ATPase activity of eIF4A to optimize 5′-UTR unwinding

Eukaryotic translation initiation requires unwinding of secondary structures in the 5′-untranslated region of mRNA. The DEAD-box helicase eIF4A is thought to unwind structural elements in the 5′-UTR in conjunction with eIF4G and eIF4B. Both factors jointly stimulate eIF4A activities by modulation of...

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Detalles Bibliográficos
Autores principales: Andreou, Alexandra Zoi, Harms, Ulf, Klostermeier, Dagmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547412/
https://www.ncbi.nlm.nih.gov/pubmed/30997503
http://dx.doi.org/10.1093/nar/gkz254

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547412/
https://www.ncbi.nlm.nih.gov/pubmed/30997503
http://dx.doi.org/10.1093/nar/gkz254

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