Deletion of Gtpbp3 in zebrafish revealed the hypertrophic cardiomyopathy manifested by aberrant mitochondrial tRNA metabolism

GTPBP3 is a highly conserved tRNA modifying enzyme for the biosynthesis of τm(5)U at the wobble position of mitochondrial tRNA(Glu), tRNA(Gln), tRNA(Lys), tRNA(Trp) and tRNA(Leu(UUR)). The previous investigations showed that GTPBP3 mutations were associated with hypertrophic cardiomyopathy (HCM). Ho...

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Detalles Bibliográficos
Autores principales: Chen, Danni, Zhang, Zengming, Chen, Chao, Yao, Shihao, Yang, Qingxian, Li, Feng, He, Xiao, Ai, Cheng, Wang, Meng, Guan, Min-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547414/
https://www.ncbi.nlm.nih.gov/pubmed/30916346
http://dx.doi.org/10.1093/nar/gkz218

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547414/
https://www.ncbi.nlm.nih.gov/pubmed/30916346
http://dx.doi.org/10.1093/nar/gkz218

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