Mammalian CST averts replication failure by preventing G-quadruplex accumulation

Human CST (CTC1-STN1-TEN1) is an RPA-like complex that associates with G-rich single-strand DNA and helps resolve replication problems both at telomeres and genome-wide. We previously showed that CST binds and disrupts G-quadruplex (G4) DNA in vitro, suggesting that CST may prevent in vivo blocks to...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Miaomiao, Wang, Bing, Li, Tingfang, Liu, Rui, Xiao, Yingnan, Geng, Xin, Li, Guang, Liu, Qiang, Price, Carolyn M, Liu, Yang, Wang, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547417/
https://www.ncbi.nlm.nih.gov/pubmed/30976812
http://dx.doi.org/10.1093/nar/gkz264

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547417/
https://www.ncbi.nlm.nih.gov/pubmed/30976812
http://dx.doi.org/10.1093/nar/gkz264

Ejemplares similares