Highly stable hexitol based XNA aptamers targeting the vascular endothelial growth factor

Biomedical applications of nucleic acid aptamers are limited by their rapid degradation in biological fluids and generally demand tedious post-selection modifications that might compromise binding. One possible solution to warrant biostability is to directly evolve chemically modified aptamers from...

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Detalles Bibliográficos
Autores principales: Eremeeva, Elena, Fikatas, Antonios, Margamuljana, Lia, Abramov, Mikhail, Schols, Dominique, Groaz, Elisabetta, Herdewijn, Piet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547419/
https://www.ncbi.nlm.nih.gov/pubmed/30968117
http://dx.doi.org/10.1093/nar/gkz252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547419/
https://www.ncbi.nlm.nih.gov/pubmed/30968117
http://dx.doi.org/10.1093/nar/gkz252

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