Cargando…

Highly stable hexitol based XNA aptamers targeting the vascular endothelial growth factor

Biomedical applications of nucleic acid aptamers are limited by their rapid degradation in biological fluids and generally demand tedious post-selection modifications that might compromise binding. One possible solution to warrant biostability is to directly evolve chemically modified aptamers from...

Descripción completa

Detalles Bibliográficos
Autores principales:	Eremeeva, Elena, Fikatas, Antonios, Margamuljana, Lia, Abramov, Mikhail, Schols, Dominique, Groaz, Elisabetta, Herdewijn, Piet
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547419/ https://www.ncbi.nlm.nih.gov/pubmed/30968117 http://dx.doi.org/10.1093/nar/gkz252

Ejemplares similares

Kinetic analysis of N-alkylaryl carboxamide hexitol nucleotides as substrates for evolved polymerases
por: Renders, Marleen, et al.
Publicado: (2019)

CRISPR-Cas9 recognition of enzymatically synthesized base-modified nucleic acids
por: Yang, Hui, et al.
Publicado: (2023)

In vitro selection of an XNA aptamer capable of small-molecule recognition
por: Rangel, Alexandra E, et al.
Publicado: (2018)

Amino-acyl tXNA as inhibitors or amino acid donors in peptide synthesis
por: Rietmeyer, Lauriane, et al.
Publicado: (2022)

Crystal structures of a natural DNA polymerase that functions as an XNA reverse transcriptase
por: Jackson, Lynnette N, et al.
Publicado: (2019)

Characterization of an HNA aptamer suggests a non-canonical G-quadruplex motif
por: Schofield, Peter, et al.
Publicado: (2023)

A microbiological system for screening the interference of XNA monomers with DNA and RNA metabolism
por: Blanchard, Aude, et al.
Publicado: (2023)

Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc–siRNA conjugates: in vitro and in vivo RNAi activity and resistance to 5′-exonuclease
por: Kumar, Pawan, et al.
Publicado: (2020)

Crystallographic analysis of engineered polymerases synthesizing phosphonomethylthreosyl nucleic acid
por: Hajjar, Mohammad, et al.
Publicado: (2022)

Xylonucleic acid: synthesis, structure, and orthogonal pairing properties
por: Maiti, Mohitosh, et al.
Publicado: (2015)

Inhibition of DNA replication by an anti-PCNA aptamer/PCNA complex
por: Kowalska, Ewa, et al.
Publicado: (2018)

Evolution of a highly functional circular DNA aptamer in serum
por: Mao, Yu, et al.
Publicado: (2020)

A DNA aptamer for binding and inhibition of DNA methyltransferase 1
por: Wang, Linlin, et al.
Publicado: (2019)

Genetically encoded RNA-based sensors with Pepper fluorogenic aptamer
por: Chen, Zhenyin, et al.
Publicado: (2023)

iSpinach: a fluorogenic RNA aptamer optimized for in vitro applications
por: Autour, Alexis, et al.
Publicado: (2016)

Tethered imidazole mediated duplex stabilization and its potential for aptamer stabilization
por: Verdonck, Lars, et al.
Publicado: (2018)

Salt-mediated two-site ligand binding by the cocaine-binding aptamer
por: Neves, Miguel A.D., et al.
Publicado: (2017)

Molecular affinity rulers: systematic evaluation of DNA aptamers for their applicabilities in ELISA
por: Kimoto, Michiko, et al.
Publicado: (2019)

G-quadruplex-forming aptamer enhances the peroxidase activity of myoglobin against luminol
por: Tsukakoshi, Kaori, et al.
Publicado: (2021)

Circular L-RNA aptamer promotes target recognition and controls gene activity
por: Ji, Danyang, et al.
Publicado: (2021)

Selective targeting of parallel G-quadruplex structure using L-RNA aptamer
por: Ji, Danyang, et al.
Publicado: (2023)

Specific suppression of D-RNA G-quadruplex–protein interaction with an L-RNA aptamer
por: Umar, Mubarak I, et al.
Publicado: (2020)

In vitro selection of l-DNA aptamers that bind a structured d-RNA molecule
por: Dey, Sougata, et al.
Publicado: (2020)

Structure–fluorescence activation relationships of a large Stokes shift fluorogenic RNA aptamer
por: Steinmetzger, Christian, et al.
Publicado: (2019)

A photochemically covalent lock stabilizes aptamer conformation and strengthens its performance for biomedicine
por: Zhou, Fang, et al.
Publicado: (2022)

Agonistic aptamer to the insulin receptor leads to biased signaling and functional selectivity through allosteric modulation
por: Yunn, Na-Oh, et al.
Publicado: (2015)

New insights into a classic aptamer: binding sites, cooperativity and more sensitive adenosine detection
por: Zhang, Zijie, et al.
Publicado: (2017)

Structural properties and anticoagulant/cytotoxic activities of heterochiral enantiomeric thrombin binding aptamer (TBA) derivatives
por: Virgilio, Antonella, et al.
Publicado: (2020)

A hotspot for enhancing insulin receptor activation revealed by a conformation-specific allosteric aptamer
por: Yunn, Na-Oh, et al.
Publicado: (2021)

Selection of 2′-deoxy-2′-fluoroarabinonucleotide (FANA) aptamers that bind HIV-1 reverse transcriptase with picomolar affinity
por: Alves Ferreira-Bravo, Irani, et al.
Publicado: (2015)

Laboratory evolution of artificially expanded DNA gives redesignable aptamers that target the toxic form of anthrax protective antigen
por: Biondi, Elisa, et al.
Publicado: (2016)

Structure guided fluorescence labeling reveals a two-step binding mechanism of neomycin to its RNA aptamer
por: Gustmann, Henrik, et al.
Publicado: (2019)

Mapping the affinity landscape of Thrombin-binding aptamers on 2΄F-ANA/DNA chimeric G-Quadruplex microarrays
por: Lietard, Jory, et al.
Publicado: (2017)

RaptRanker: in silico RNA aptamer selection from HT-SELEX experiment based on local sequence and structure information
por: Ishida, Ryoga, et al.
Publicado: (2020)

What defines a synthetic riboswitch? – Conformational dynamics of ciprofloxacin aptamers with similar binding affinities but varying regulatory potentials
por: Kaiser, Christoph, et al.
Publicado: (2021)

Polymerase-catalyzed synthesis of DNA from phosphoramidate conjugates of deoxynucleotides and amino acids
por: Adelfinskaya, O., et al.
Publicado: (2007)

Switching the activity of Taq polymerase using clamp-like triplex aptamer structure
por: Hu, Yingxin, et al.
Publicado: (2020)

Site-specific replacement of the thymine methyl group by fluorine in thrombin binding aptamer significantly improves structural stability and anticoagulant activity
por: Virgilio, Antonella, et al.
Publicado: (2015)

The cotranscriptional folding landscape for two cyclic di-nucleotide-sensing riboswitches with highly homologous aptamer domains acting either as ON- or OFF-switches
por: Landgraf, Tom, et al.
Publicado: (2022)

A highly specific sodium aptamer probed by 2-aminopurine for robust Na(+) sensing
por: Zhou, Wenhu, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_ar4jjvaitksh64ftpgkmealt2s