A 5′-to-3′ strand exchange polarity is intrinsic to RecA nucleoprotein filaments in the absence of ATP hydrolysis

RecA is essential to recombinational DNA repair in which RecA filaments mediate the homologous DNA pairing and strand exchange. Both RecA filament assembly and the subsequent DNA strand exchange are directional. Here, we demonstrate that the polarity of DNA strand exchange is embedded within RecA fi...

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Detalles Bibliográficos
Autores principales: Lin, Yu-Hsuan, Chu, Chia-Chieh, Fan, Hsiu-Fang, Wang, Pang-Yen, Cox, Michael M, Li, Hung-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547424/
https://www.ncbi.nlm.nih.gov/pubmed/30916331
http://dx.doi.org/10.1093/nar/gkz189

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547424/
https://www.ncbi.nlm.nih.gov/pubmed/30916331
http://dx.doi.org/10.1093/nar/gkz189

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