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AIControl: replacing matched control experiments with machine learning improves ChIP-seq peak identification

ChIP-seq is a technique to determine binding locations of transcription factors, which remains a central challenge in molecular biology. Current practice is to use a ‘control’ dataset to remove background signals from a immunoprecipitation (IP) ‘target’ dataset. We introduce the AIControl framework,...

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Detalles Bibliográficos
Autores principales: Hiranuma, Naozumi, Lundberg, Scott M, Lee, Su-In
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547432/
https://www.ncbi.nlm.nih.gov/pubmed/30869146
http://dx.doi.org/10.1093/nar/gkz156