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AIControl: replacing matched control experiments with machine learning improves ChIP-seq peak identification
ChIP-seq is a technique to determine binding locations of transcription factors, which remains a central challenge in molecular biology. Current practice is to use a ‘control’ dataset to remove background signals from a immunoprecipitation (IP) ‘target’ dataset. We introduce the AIControl framework,...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547432/ https://www.ncbi.nlm.nih.gov/pubmed/30869146 http://dx.doi.org/10.1093/nar/gkz156 |