Charting DENR-dependent translation reinitiation uncovers predictive uORF features and links to circadian timekeeping via Clock

The non-canonical initiation factor DENR promotes translation reinitiation on mRNAs harbouring upstream open reading frames (uORFs). Moreover, DENR depletion shortens circadian period in mouse fibroblasts, suggesting involvement of uORF usage and reinitiation in clock regulation. To identify DENR-re...

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Detalles Bibliográficos
Autores principales: Castelo-Szekely, Violeta, De Matos, Mara, Tusup, Marina, Pascolo, Steve, Ule, Jernej, Gatfield, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547434/
https://www.ncbi.nlm.nih.gov/pubmed/30982898
http://dx.doi.org/10.1093/nar/gkz261

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547434/
https://www.ncbi.nlm.nih.gov/pubmed/30982898
http://dx.doi.org/10.1093/nar/gkz261

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