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Cas4–Cas1 fusions drive efficient PAM selection and control CRISPR adaptation
Microbes have the unique ability to acquire immunological memories from mobile genetic invaders to protect themselves from predation. To confer CRISPR resistance, new spacers need to be compatible with a targeting requirement in the invader's DNA called the protospacer adjacent motif (PAM). Man...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547450/ https://www.ncbi.nlm.nih.gov/pubmed/30937444 http://dx.doi.org/10.1093/nar/gkz217 |