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Toxoplasma gondii ROP18 inhibits human glioblastoma cell apoptosis through a mitochondrial pathway by targeting host cell P2X1

BACKGROUND: Apoptosis plays a critical role in the embryonic development, homeostasis of immune system and host defense against intracellular microbial pathogens. Infection by the obligate intracellular pathogen Toxoplasma gondii can both inhibit and induce host cell apoptosis; however, the parasiti...

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Detalles Bibliográficos
Autores principales: Zhou, Li-Juan, Chen, Min, Puthiyakunnon, Santhosh, He, Cheng, Xia, Jing, He, Cynthia Y., Deng, Sheng-Qun, Peng, Hong-Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547611/
https://www.ncbi.nlm.nih.gov/pubmed/31164145
http://dx.doi.org/10.1186/s13071-019-3529-1