Cargando…
New insights into YAP/TAZ nucleo‐cytoplasmic shuttling: new cancer therapeutic opportunities?
Yes‐associated protein (YAP) and transcriptional co‐activator with PDZ‐binding motif (TAZ), the main effectors of the Hippo pathway, are emerging as important players in cancer biology and therapy response. The intracellular localization of YAP/TAZ is a key determinant in the regulation of their act...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547617/ https://www.ncbi.nlm.nih.gov/pubmed/31050214 http://dx.doi.org/10.1002/1878-0261.12498 |
_version_ | 1783423719051362304 |
---|---|
author | Shreberk‐Shaked, Michal Oren, Moshe |
author_facet | Shreberk‐Shaked, Michal Oren, Moshe |
author_sort | Shreberk‐Shaked, Michal |
collection | PubMed |
description | Yes‐associated protein (YAP) and transcriptional co‐activator with PDZ‐binding motif (TAZ), the main effectors of the Hippo pathway, are emerging as important players in cancer biology and therapy response. The intracellular localization of YAP/TAZ is a key determinant in the regulation of their activity and their roles in signal transduction. This is particularly relevant for cancer: Aberrant nuclear localization of YAP and TAZ has been observed in numerous human cancers and may therefore represent an attractive target for cancer therapy. In this review, we describe the mechanisms that regulate the nucleo‐cytoplasmic shuttling of YAP/TAZ and their implications for cancer, and discuss how the new insights about this process may pave the way for novel therapeutic strategies. |
format | Online Article Text |
id | pubmed-6547617 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65476172019-06-06 New insights into YAP/TAZ nucleo‐cytoplasmic shuttling: new cancer therapeutic opportunities? Shreberk‐Shaked, Michal Oren, Moshe Mol Oncol Review Article Yes‐associated protein (YAP) and transcriptional co‐activator with PDZ‐binding motif (TAZ), the main effectors of the Hippo pathway, are emerging as important players in cancer biology and therapy response. The intracellular localization of YAP/TAZ is a key determinant in the regulation of their activity and their roles in signal transduction. This is particularly relevant for cancer: Aberrant nuclear localization of YAP and TAZ has been observed in numerous human cancers and may therefore represent an attractive target for cancer therapy. In this review, we describe the mechanisms that regulate the nucleo‐cytoplasmic shuttling of YAP/TAZ and their implications for cancer, and discuss how the new insights about this process may pave the way for novel therapeutic strategies. John Wiley and Sons Inc. 2019-05-17 2019-06 /pmc/articles/PMC6547617/ /pubmed/31050214 http://dx.doi.org/10.1002/1878-0261.12498 Text en © 2019 The Authors. Published by FEBS Press and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Shreberk‐Shaked, Michal Oren, Moshe New insights into YAP/TAZ nucleo‐cytoplasmic shuttling: new cancer therapeutic opportunities? |
title | New insights into YAP/TAZ nucleo‐cytoplasmic shuttling: new cancer therapeutic opportunities? |
title_full | New insights into YAP/TAZ nucleo‐cytoplasmic shuttling: new cancer therapeutic opportunities? |
title_fullStr | New insights into YAP/TAZ nucleo‐cytoplasmic shuttling: new cancer therapeutic opportunities? |
title_full_unstemmed | New insights into YAP/TAZ nucleo‐cytoplasmic shuttling: new cancer therapeutic opportunities? |
title_short | New insights into YAP/TAZ nucleo‐cytoplasmic shuttling: new cancer therapeutic opportunities? |
title_sort | new insights into yap/taz nucleo‐cytoplasmic shuttling: new cancer therapeutic opportunities? |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547617/ https://www.ncbi.nlm.nih.gov/pubmed/31050214 http://dx.doi.org/10.1002/1878-0261.12498 |
work_keys_str_mv | AT shreberkshakedmichal newinsightsintoyaptaznucleocytoplasmicshuttlingnewcancertherapeuticopportunities AT orenmoshe newinsightsintoyaptaznucleocytoplasmicshuttlingnewcancertherapeuticopportunities |