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New insights into YAP/TAZ nucleo‐cytoplasmic shuttling: new cancer therapeutic opportunities?

Yes‐associated protein (YAP) and transcriptional co‐activator with PDZ‐binding motif (TAZ), the main effectors of the Hippo pathway, are emerging as important players in cancer biology and therapy response. The intracellular localization of YAP/TAZ is a key determinant in the regulation of their act...

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Detalles Bibliográficos
Autores principales: Shreberk‐Shaked, Michal, Oren, Moshe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547617/
https://www.ncbi.nlm.nih.gov/pubmed/31050214
http://dx.doi.org/10.1002/1878-0261.12498
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author Shreberk‐Shaked, Michal
Oren, Moshe
author_facet Shreberk‐Shaked, Michal
Oren, Moshe
author_sort Shreberk‐Shaked, Michal
collection PubMed
description Yes‐associated protein (YAP) and transcriptional co‐activator with PDZ‐binding motif (TAZ), the main effectors of the Hippo pathway, are emerging as important players in cancer biology and therapy response. The intracellular localization of YAP/TAZ is a key determinant in the regulation of their activity and their roles in signal transduction. This is particularly relevant for cancer: Aberrant nuclear localization of YAP and TAZ has been observed in numerous human cancers and may therefore represent an attractive target for cancer therapy. In this review, we describe the mechanisms that regulate the nucleo‐cytoplasmic shuttling of YAP/TAZ and their implications for cancer, and discuss how the new insights about this process may pave the way for novel therapeutic strategies.
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spelling pubmed-65476172019-06-06 New insights into YAP/TAZ nucleo‐cytoplasmic shuttling: new cancer therapeutic opportunities? Shreberk‐Shaked, Michal Oren, Moshe Mol Oncol Review Article Yes‐associated protein (YAP) and transcriptional co‐activator with PDZ‐binding motif (TAZ), the main effectors of the Hippo pathway, are emerging as important players in cancer biology and therapy response. The intracellular localization of YAP/TAZ is a key determinant in the regulation of their activity and their roles in signal transduction. This is particularly relevant for cancer: Aberrant nuclear localization of YAP and TAZ has been observed in numerous human cancers and may therefore represent an attractive target for cancer therapy. In this review, we describe the mechanisms that regulate the nucleo‐cytoplasmic shuttling of YAP/TAZ and their implications for cancer, and discuss how the new insights about this process may pave the way for novel therapeutic strategies. John Wiley and Sons Inc. 2019-05-17 2019-06 /pmc/articles/PMC6547617/ /pubmed/31050214 http://dx.doi.org/10.1002/1878-0261.12498 Text en © 2019 The Authors. Published by FEBS Press and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Shreberk‐Shaked, Michal
Oren, Moshe
New insights into YAP/TAZ nucleo‐cytoplasmic shuttling: new cancer therapeutic opportunities?
title New insights into YAP/TAZ nucleo‐cytoplasmic shuttling: new cancer therapeutic opportunities?
title_full New insights into YAP/TAZ nucleo‐cytoplasmic shuttling: new cancer therapeutic opportunities?
title_fullStr New insights into YAP/TAZ nucleo‐cytoplasmic shuttling: new cancer therapeutic opportunities?
title_full_unstemmed New insights into YAP/TAZ nucleo‐cytoplasmic shuttling: new cancer therapeutic opportunities?
title_short New insights into YAP/TAZ nucleo‐cytoplasmic shuttling: new cancer therapeutic opportunities?
title_sort new insights into yap/taz nucleo‐cytoplasmic shuttling: new cancer therapeutic opportunities?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547617/
https://www.ncbi.nlm.nih.gov/pubmed/31050214
http://dx.doi.org/10.1002/1878-0261.12498
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