AMPK activation induced in pemetrexed‐treated cells is associated with development of drug resistance independently of target enzyme expression

Pemetrexed (PEM) inhibits DNA and RNA synthesis and is currently one of the first‐line agents for mesothelioma. PEM suppresses the activities of several enzymes involved in purine and pyrimidine synthesis, and elevated activity of these enzymes in tumors is often linked with resistance to PEM. The a...

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Detalles Bibliográficos
Autores principales: Qin, Yiyang, Sekine, Ikuo, Hanazono, Michiko, Morinaga, Takao, Fan, Mengmeng, Takiguchi, Yuichi, Tada, Yuji, Shingyoji, Masato, Yamaguchi, Naoto, Tagawa, Masatoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547620/
https://www.ncbi.nlm.nih.gov/pubmed/31033201
http://dx.doi.org/10.1002/1878-0261.12496

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547620/
https://www.ncbi.nlm.nih.gov/pubmed/31033201
http://dx.doi.org/10.1002/1878-0261.12496

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