Functional testing of thousands of osteoarthritis-associated variants for regulatory activity

To date, genome-wide association studies have implicated at least 35 loci in osteoarthritis but, due to linkage disequilibrium, the specific variants underlying these associations and the mechanisms by which they contribute to disease risk have yet to be pinpointed. Here, we functionally test 1,605...

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Detalles Bibliográficos
Autores principales: Klein, Jason C., Keith, Aidan, Rice, Sarah J., Shepherd, Colin, Agarwal, Vikram, Loughlin, John, Shendure, Jay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547687/
https://www.ncbi.nlm.nih.gov/pubmed/31164647
http://dx.doi.org/10.1038/s41467-019-10439-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547687/
https://www.ncbi.nlm.nih.gov/pubmed/31164647
http://dx.doi.org/10.1038/s41467-019-10439-y

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