The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing

DNA replication initiation is a two-step process. During the G1-phase of the cell cycle, the ORC complex, CDC6, CDT1, and MCM2–7 assemble at replication origins, forming pre-replicative complexes (pre-RCs). In S-phase, kinase activities allow fork establishment through (CDC45/MCM2–7/GINS) CMG-comple...

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Detalles Bibliográficos
Autores principales: Coulombe, Philippe, Nassar, Joelle, Peiffer, Isabelle, Stanojcic, Slavica, Sterkers, Yvon, Delamarre, Axel, Bocquet, Stéphane, Méchali, Marcel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547688/
https://www.ncbi.nlm.nih.gov/pubmed/31160578
http://dx.doi.org/10.1038/s41467-019-10321-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547688/
https://www.ncbi.nlm.nih.gov/pubmed/31160578
http://dx.doi.org/10.1038/s41467-019-10321-x

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