Cargando…

Aβ-induced vulnerability propagates via the brain’s default mode network

The link between brain amyloid-β (Aβ), metabolism, and dementia symptoms remains a pressing question in Alzheimer’s disease. Here, using positron emission tomography ([(18)F]florbetapir tracer for Aβ and [(18)F]FDG tracer for glucose metabolism) with a novel analytical framework, we found that Aβ ag...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pascoal, Tharick A., Mathotaarachchi, Sulantha, Kang, Min Su, Mohaddes, Sara, Shin, Monica, Park, Ah Yeon, Parent, Maxime J., Benedet, Andrea L., Chamoun, Mira, Therriault, Joseph, Hwang, Heungsun, Cuello, A. Claudio, Misic, Bratislav, Soucy, Jean-Paul, Aston, John A. D., Gauthier, Serge, Rosa-Neto, Pedro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547716/ https://www.ncbi.nlm.nih.gov/pubmed/31164641 http://dx.doi.org/10.1038/s41467-019-10217-w

Ejemplares similares

Topographical distribution of Aβ predicts progression to dementia in Aβ positive mild cognitive impairment
por: Pascoal, Tharick A., et al.
Publicado: (2020)

Anosognosia predicts default mode network hypometabolism and clinical progression to dementia
por: Therriault, Joseph, et al.
Publicado: (2018)

Association between regional tau pathology and neuropsychiatric symptoms in aging and dementia due to Alzheimer's disease
por: Tissot, Cécile, et al.
Publicado: (2021)

Rasagiline, a monoamine oxidase B inhibitor, reduces in vivo [(18)F]THK5351 uptake in progressive supranuclear palsy
por: Ng, Kok Pin, et al.
Publicado: (2019)

Amyloid‐dependent and amyloid‐independent effects of Tau in individuals without dementia
por: Therriault, Joseph, et al.
Publicado: (2021)

In vivo quantification of neurofibrillary tangles with [(18)F]MK-6240
por: Pascoal, Tharick A., et al.
Publicado: (2018)

APOEε4 potentiates the relationship between amyloid-β and tau pathologies
por: Therriault, Joseph, et al.
Publicado: (2020)

Amyloid-beta modulates the association between neurofilament light chain and brain atrophy in Alzheimer’s disease
por: Kang, Min Su, et al.
Publicado: (2020)

Plasma neurofilament light associates with Alzheimer's disease metabolic decline in amyloid-positive individuals
por: Benedet, Andréa L., et al.
Publicado: (2019)

Association of plasma P-tau181 with memory decline in non-demented adults
por: Therriault, Joseph, et al.
Publicado: (2021)

Impact of long- and short-range fibre depletion on the cognitive deficits of fronto-temporal dementia
por: Savard, Melissa, et al.
Publicado: (2022)

Amyloid and tau signatures of brain metabolic decline in preclinical Alzheimer’s disease
por: Pascoal, Tharick A., et al.
Publicado: (2018)

Neuropsychiatric symptoms are early indicators of an upcoming metabolic decline in Alzheimer’s disease
por: Ng, Kok Pin, et al.
Publicado: (2021)

Cerebrospinal fluid p-tau231 as an early indicator of emerging pathology in Alzheimer's disease
por: Ashton, Nicholas J., et al.
Publicado: (2022)

Characterizing biomarker features of cognitively normal individuals with ventriculomegaly
por: Li, Xiaofeng, et al.
Publicado: (2017)

The prevalence and biomarkers’ characteristic of rapidly progressive Alzheimer's disease from the Alzheimer's Disease Neuroimaging Initiative database
por: Ba, Maowen, et al.
Publicado: (2017)

Mild behavioral impairment is associated with β‐amyloid but not tau or neurodegeneration in cognitively intact elderly individuals
por: Lussier, Firoza Z., et al.
Publicado: (2020)

Interactive rather than independent effect of APOE and sex potentiates tau deposition in women
por: Wang, Yi-Ting T, et al.
Publicado: (2021)

VoxelStats: A MATLAB Package for Multi-Modal Voxel-Wise Brain Image Analysis
por: Mathotaarachchi, Sulantha, et al.
Publicado: (2016)

Monoamine oxidase B inhibitor, selegiline, reduces (18)F-THK5351 uptake in the human brain
por: Ng, Kok Pin, et al.
Publicado: (2017)

Plasma levels of phosphorylated tau 181 are associated with cerebral metabolic dysfunction in cognitively impaired and amyloid-positive individuals
por: Lussier, Firoza Z, et al.
Publicado: (2021)

CYP2C19 variant mitigates Alzheimer disease pathophysiology in vivo and postmortem
por: Benedet, Andréa L., et al.
Publicado: (2018)

Author Correction: [(11)C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer’s disease
por: Pascoal, Tharick A., et al.
Publicado: (2022)

[(11)C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer’s disease
por: Pascoal, Tharick A., et al.
Publicado: (2022)

Neuropsychiatric symptoms predict hypometabolism in preclinical Alzheimer disease
por: Ng, Kok Pin, et al.
Publicado: (2017)

Frequency of Biologically Defined Alzheimer Disease in Relation to Age, Sex, APOE ε4, and Cognitive Impairment
por: Therriault, Joseph, et al.
Publicado: (2021)

Topographic Distribution of Amyloid-β, Tau, and Atrophy in Patients With Behavioral/Dysexecutive Alzheimer Disease
por: Therriault, Joseph, et al.
Publicado: (2021)

Plasma pTau181 predicts cortical brain atrophy in aging and Alzheimer’s disease
por: Tissot, Cécile, et al.
Publicado: (2021)

Epistasis analysis links immune cascades and cerebral amyloidosis
por: Benedet, Andréa L., et al.
Publicado: (2015)

Discriminative accuracy of the A/T/N scheme to identify cognitive impairment due to Alzheimer's disease
por: Pascoal, Tharick A., et al.
Publicado: (2023)

Vascular retinal biomarkers improves the detection of the likely cerebral amyloid status from hyperspectral retinal images
por: Sharafi, Sayed Mehran, et al.
Publicado: (2019)

Verbal memory formation across PET-based Braak stages of tau accumulation in Alzheimer’s disease
por: Fernández Arias, Jaime, et al.
Publicado: (2023)

Comparing tau status determined via plasma pTau181, pTau231 and [(18)F]MK6240 tau-PET
por: Tissot, Cécile, et al.
Publicado: (2022)

Biomarker modeling of Alzheimer’s disease using PET-based Braak staging
por: Therriault, Joseph, et al.
Publicado: (2022)

Cerebrospinal fluid synaptosomal-associated protein 25 is a key player in synaptic degeneration in mild cognitive impairment and Alzheimer’s disease
por: Zhang, Hua, et al.
Publicado: (2018)

Cerebrospinal fluid phosphorylated tau, visinin-like protein-1, and chitinase-3-like protein 1 in mild cognitive impairment and Alzheimer’s disease
por: Zhang, Hua, et al.
Publicado: (2018)

Amyloid-β and hyperphosphorylated tau synergy drives metabolic decline in preclinical Alzheimer's disease
por: Pascoal, T A, et al.
Publicado: (2017)

Local vulnerability and global connectivity jointly shape neurodegenerative disease propagation
por: Zheng, Ying-Qiu, et al.
Publicado: (2019)

Characterization of an automated method to segment the human locus coeruleus
por: Sibahi, Ahmad, et al.
Publicado: (2023)

Dynamic Amyloid and Metabolic Signatures of Delayed Recall Performance within the Clinical Spectrum of Alzheimer’s Disease
por: Tedeschi Dauar, Marina, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_hr47mfmomuh5mkrdtojg8v82dj