Cargando…

Potent and specific MTH1 inhibitors targeting gastric cancer

Human mutT homolog 1(MTH1), the oxidized dNTP pool sanitizer enzyme, has been reported to be highly expressed in various malignant tumors. However, the oncogenic role of MTH1 in gastric cancer remains to be determined. In the current study, we found that MTH1 was overexpressed in human gastric cance...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Wenjuan, Ma, Liying, Yang, Jing, Qiao, Hui, Li, Lingyu, Guo, Qian, Ma, Jinlian, Zhao, Lijuan, Wang, Junwei, Jiang, Guozhong, Wan, Xiangbin, Adam Goscinski, Mariusz, Ding, Lina, Zheng, Yichao, Li, Wencai, Liu, Hongmin, Suo, Zhenhe, Zhao, Wen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547740/ https://www.ncbi.nlm.nih.gov/pubmed/31164636 http://dx.doi.org/10.1038/s41419-019-1665-3

Ejemplares similares

Correction: Potent and specific MTH1 inhibitors targeting gastric cancer
por: Zhou, Wenjuan, et al.
Publicado: (2020)

Development of the triazole-fused pyrimidine derivatives as highly potent and reversible inhibitors of histone lysine specific demethylase 1 (LSD1/KDM1A)
por: Li, Zhonghua, et al.
Publicado: (2019)

Oncogenic Role of Guanylate Binding Protein 1 in Human Prostate Cancer
por: Zhao, Jing, et al.
Publicado: (2020)

High SRPX2 protein expression predicts unfavorable clinical outcome in patients with prostate cancer
por: Zhang, Meng, et al.
Publicado: (2018)

Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2
por: Carter, Megan, et al.
Publicado: (2015)

Exploration of 5-cyano-6-phenylpyrimidin derivatives containing an 1,2,3-triazole moiety as potent FAD-based LSD1 inhibitors
por: Ma, Liying, et al.
Publicado: (2020)

MTH1 protects platelet mitochondria from oxidative damage and regulates platelet function and thrombosis
por: Ding, Yangyang, et al.
Publicado: (2023)

The allosteric gating mechanism of the MthK channel
por: Guan, Fenghui, et al.
Publicado: (2022)

USP7: Novel Drug Target in Cancer Therapy
por: Wang, Zhiru, et al.
Publicado: (2019)

MTH1 counteracts oncogenic oxidative stress
por: Burton, Dominick G.A., et al.
Publicado: (2015)

Polyamine block of MthK potassium channels
por: Nimigean, Crina M.
Publicado: (2020)

Abrogation of USP7 is an alternative strategy to downregulate PD-L1 and sensitize gastric cancer cells to T cells killing
por: Wang, Zhiru, et al.
Publicado: (2021)

MTH1 inhibitor amplifies the lethality of reactive oxygen species to tumor in photodynamic therapy
por: Zhao, Lingzhi, et al.
Publicado: (2020)

Establishment of mitochondrial pyruvate carrier 1 (MPC1) gene knockout mice with preliminary gene function analyses
por: Li, Xiaoli, et al.
Publicado: (2016)

Stereospecific targeting of MTH1 by (S)-crizotinib as anticancer strategy
por: Huber, Kilian V. M., et al.
Publicado: (2014)

MTH1 Substrate Recognition—An Example of Specific Promiscuity
por: Nissink, J. Willem M., et al.
Publicado: (2016)

MTH1 as a Chemotherapeutic Target: The Elephant in the Room
por: Samaranayake, Govindi J., et al.
Publicado: (2017)

MPC1 and MPC2 expressions are associated with favorable clinical outcomes in prostate cancer
por: Li, Xiaoli, et al.
Publicado: (2016)

Mitochondrial pyruvate carrier function determines cell stemness and metabolic reprogramming in cancer cells
por: Li, Xiaoli, et al.
Publicado: (2017)

PDHA1 gene knockout in prostate cancer cells results in metabolic reprogramming towards greater glutamine dependence
por: Li, Yaqing, et al.
Publicado: (2016)

Mitochondrial pyruvate carrier function is negatively linked to Warburg phenotype in vitro and malignant features in esophageal squamous cell carcinomas
por: Li, Yaqing, et al.
Publicado: (2016)

MTH1 expression is required for effective transformation by oncogenic HRAS
por: Giribaldi, Maria G., et al.
Publicado: (2015)

Glioblastoma and glioblastoma stem cells are dependent on functional MTH1
por: Pudelko, Linda, et al.
Publicado: (2017)

Polyamine blockade and binding energetics in the MthK potassium channel
por: Suma, Antonio, et al.
Publicado: (2020)

Farnesyl phenolic enantiomers as natural MTH1 inhibitors from Ganoderma sinense
por: Gao, Ya, et al.
Publicado: (2017)

Study on the intracellular adaptative mechanism of Acidithiobacillus caldus MTH-04 to NaCl stress
por: Li, Min, et al.
Publicado: (2023)

Calcium-dependent Gating of MthK, a Prokaryotic Potassium Channel
por: Zadek, Brittany, et al.
Publicado: (2006)

Influence of gastrocnemius-soleus muscle force on sub-MTH load distribution
por: Chen, Wen-Ming, et al.
Publicado: (2012)

Ionic interactions of Ba(2+) blockades in the MthK K(+) channel
por: Guo, Rui, et al.
Publicado: (2014)

Without Salt, the ‘Thermophilic’ Protein Mth10b Is Just Mesophilic
por: Zhang, Nan, et al.
Publicado: (2012)

Probing the Folding-Unfolding Transition of a Thermophilic Protein, MTH1880
por: Kim, Heeyoun, et al.
Publicado: (2016)

A comparison of X-ray and calculated structures of the enzyme MTH1
por: Ryan, Hannah, et al.
Publicado: (2016)

Correction: Glioblastoma and glioblastoma stem cells are dependent on functional MTH1
por: Pudelko, Linda, et al.
Publicado: (2020)

Activation of the archaeal ion channel MthK is exquisitely regulated by temperature
por: Jiang, Yihao, et al.
Publicado: (2020)

Gating and Inward Rectifying Properties of the MthK K(+) Channel with and without the Gating Ring
por: Li, Yang, et al.
Publicado: (2007)

MtDNA depleted PC3 cells exhibit Warburg effect and cancer stem cell features
por: Li, Xiaoran, et al.
Publicado: (2016)

Correction: MtDNA depleted PC3 cells exhibit Warburg effect and cancer stem cell features
por: Li, Xiaoran, et al.
Publicado: (2017)

Generation of an oxoglutarate dehydrogenase knockout rat model and the effect of a high-fat diet
por: Fan, Zhirui, et al.
Publicado: (2018)

Voltage-dependent inactivation gating at the selectivity filter of the MthK K(+) channel
por: Thomson, Andrew S., et al.
Publicado: (2010)

The voltage-dependent gate in MthK potassium channels is located at the selectivity filter
por: Posson, David J., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_qo9lbcmlqlsvllo4npf3eht20h