c-kit Haploinsufficiency impairs adult cardiac stem cell growth, myogenicity and myocardial regeneration

An overdose of Isoproterenol (ISO) causes acute cardiomyocyte (CM) dropout and activates the resident cardiac c-kit(pos) stem/progenitor cells (CSCs) generating a burst of new CM formation that replaces those lost to ISO. Recently, unsuccessful attempts to reproduce these findings using c-kit(Cre) k...

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Detalles Bibliográficos
Autores principales: Aquila, Iolanda, Cianflone, Eleonora, Scalise, Mariangela, Marino, Fabiola, Mancuso, Teresa, Filardo, Andrea, Smith, Andrew J., Cappetta, Donato, De Angelis, Antonella, Urbanek, Konrad, Isidori, Andrea M., Torella, Michele, Agosti, Valter, Viglietto, Giuseppe, Nadal-Ginard, Bernardo, Ellison-Hughes, Georgina M., Torella, Daniele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547756/
https://www.ncbi.nlm.nih.gov/pubmed/31164633
http://dx.doi.org/10.1038/s41419-019-1655-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547756/
https://www.ncbi.nlm.nih.gov/pubmed/31164633
http://dx.doi.org/10.1038/s41419-019-1655-5

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