A novel human IL2RB mutation results in T and NK cell–driven immune dysregulation

The pleiotropic actions of interleukin-2 (IL-2) are essential for regulation of immune responses and maintenance of immune tolerance. The IL-2 receptor (IL-2R) is composed of IL-2Rα, IL-2Rβ, and IL-2Rγ subunits, with defects in IL-2Rα and IL-2Rγ and their downstream signaling effectors resulting in...

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Detalles Bibliográficos
Autores principales: Fernandez, Isabel Z., Baxter, Ryan M., Garcia-Perez, Josselyn E., Vendrame, Elena, Ranganath, Thanmayi, Kong, Daniel S., Lundquist, Karl, Nguyen, Tom, Ogolla, Sidney, Black, Jennifer, Galambos, Csaba, Gumbart, James C., Dawany, Noor, Kelsen, Judith R., de Zoeten, Edwin F., Quinones, Ralph, Eissa, Hesham, Verneris, Michael R., Sullivan, Kathleen E., Rochford, Rosemary, Blish, Catherine A., Kedl, Ross M., Dutmer, Cullen M., Hsieh, Elena W.Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547857/
https://www.ncbi.nlm.nih.gov/pubmed/31040184
http://dx.doi.org/10.1084/jem.20182015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547857/
https://www.ncbi.nlm.nih.gov/pubmed/31040184
http://dx.doi.org/10.1084/jem.20182015

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