Oncogenic kinase inhibition limits Batf3-dependent dendritic cell development and antitumor immunity

Gastrointestinal stromal tumor (GIST) is driven by an activating mutation in the KIT proto-oncogene. Using a mouse model of GIST and human specimens, we show that intratumoral murine CD103(+)CD11b(−) dendritic cells (DCs) and human CD141(+) DCs are associated with CD8(+) T cell infiltration and diff...

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Detalles Bibliográficos
Autores principales: Medina, Benjamin D., Liu, Mengyuan, Vitiello, Gerardo A., Seifert, Adrian M., Zeng, Shan, Bowler, Timothy, Zhang, Jennifer Q., Cavnar, Michael J., Loo, Jennifer K., Param, Nesteene J., Maltbaek, Joanna H., Rossi, Ferdinand, Balachandran, Vinod, DeMatteo, Ronald P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547861/
https://www.ncbi.nlm.nih.gov/pubmed/31000683
http://dx.doi.org/10.1084/jem.20180660

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547861/
https://www.ncbi.nlm.nih.gov/pubmed/31000683
http://dx.doi.org/10.1084/jem.20180660

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