Cargando…

T cell anergy in perinatal mice is promoted by T reg cells and prevented by IL-33

Perinatal T cells broadly access nonlymphoid tissues, where they are exposed to sessile tissue antigens. To probe the outcome of such encounters, we examined the defective elimination of self-reactive clones in Aire-deficient mice. Nonlymphoid tissues were sequentially seeded by distinct waves of CD...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tuncel, Jonatan, Benoist, Christophe, Mathis, Diane
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547863/ https://www.ncbi.nlm.nih.gov/pubmed/30988052 http://dx.doi.org/10.1084/jem.20182002

Ejemplares similares

Number of T Reg Cells That Differentiate Does Not Increase upon Encounter of Agonist Ligand on Thymic Epithelial Cells
por: van Santen, Hisse-Martien, et al.
Publicado: (2004)

Where CD4(+)CD25(+) T reg cells impinge on autoimmune diabetes
por: Chen, Zhibin, et al.
Publicado: (2005)

An intrinsic role of IL-33 in T(reg) cell-mediated tumor immunoevasion
por: Hatzioannou, Aikaterini, et al.
Publicado: (2019)

PPARγ is a major driver of the accumulation and phenotype of adipose-tissue T(reg) cells
por: Cipolletta, Daniela, et al.
Publicado: (2012)

Regulatory T cells control NK cells in an insulitic lesion by depriving them of IL-2
por: Sitrin, Jonathan, et al.
Publicado: (2013)

Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunity
por: Guerau-de-Arellano, Mireia, et al.
Publicado: (2009)

Cbl-b deficiency prevents functional but not phenotypic T cell anergy
por: Nguyen, Trang T.T., et al.
Publicado: (2021)

IL-17A–producing γδT cells promote muscle regeneration in a microbiota-dependent manner
por: Mann, Alexander O., et al.
Publicado: (2022)

Adaptive plasticity of IL-10(+) and IL-35(+) T(reg) cells cooperatively promotes tumor T cell exhaustion
por: Sawant, Deepali V., et al.
Publicado: (2019)

Bcl11b prevents fatal autoimmunity by promoting T(reg) cell program and constraining innate lineages in T(reg) cells
por: Drashansky, Theodore T., et al.
Publicado: (2019)

A revival of the B cell paradigm for rheumatoid arthritis pathogenesis?
por: Benoist, Christophe, et al.
Publicado: (2000)

CD4(+) T cell anergy prevents autoimmunity and generates regulatory T cell precursors
por: Kalekar, Lokesh A., et al.
Publicado: (2016)

Interleukin-33 Promotes REG3γ Expression in Intestinal Epithelial Cells and Regulates Gut Microbiota
por: Xiao, Yi, et al.
Publicado: (2019)

CD4(+)CD25(+) T Regulatory Cells Dependent on ICOS Promote Regulation of Effector Cells in the Prediabetic Lesion
por: Herman, Ann E., et al.
Publicado: (2004)

IL‐3 is essential for ICOS‐L stabilization on mast cells, and sustains the IL‐33‐induced RORγt(+) T(reg) generation via enhanced IL‐6 induction
por: Drube, Sebastian, et al.
Publicado: (2021)

CTLA-4 on thymic epithelial cells complements Aire for T cell central tolerance
por: Michelson, Daniel A., et al.
Publicado: (2022)

IL-35 improves T(reg)-mediated immune suppression in atherosclerotic mice
por: Tao, Linlin, et al.
Publicado: (2016)

The AKT–mTOR axis regulates de novo differentiation of CD4(+)Foxp3(+) cells
por: Haxhinasto, Sokol, et al.
Publicado: (2008)

NK Cell Induced T Cell Anergy Depends on GRAIL Expression
por: Galazka, Grazyna, et al.
Publicado: (2019)

Fully competent dendritic cells as inducers of T cell anergy in autoimmunity
por: Quaratino, S, et al.
Publicado: (2001)

A role for immunotherapy: preventing macrophage anergy in the tumour environment
por: Elia, Androulla, et al.
Publicado: (2013)

IL-33 promotes IL-10 production in macrophages: a role for IL-33 in macrophage foam cell formation
por: Zhang, Hai-Feng, et al.
Publicado: (2017)

Synergistic Activations of REG Iα and REG I β Promoters by IL-6 and Glucocorticoids through JAK/STAT Pathway in Human Pancreatic β Cells
por: Yamauchi, Akiyo, et al.
Publicado: (2015)

Role of Interleukin 12 and Costimulators in T Cell Anergy In Vivo
por: Parijs, Luk Van, et al.
Publicado: (1997)

Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance
Publicado: (1995)

Models of T cell anergy: is there a common molecular mechanism?
Publicado: (1996)

Role of interleukin 12 and costimulators in T cell anergy in vivo
por: Van Parijs, Luk, et al.
Publicado: (2009)

Uncovering the mechanisms that regulate tumor-induced T-cell anergy
por: Abe, Brian T., et al.
Publicado: (2013)

TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets
por: Wong, Jamie, et al.
Publicado: (2007)

Developmental and cellular age direct conversion of CD4(+) T cells into RORγ(+) or Helios(+) colon Treg cells
por: Pratama, Alvin, et al.
Publicado: (2019)

Lymphocyte Anergy in Patients with Carcinoma
por: Nind, A. P. P., et al.
Publicado: (1973)

Thymic negative selection is functional in NOD mice
por: Mingueneau, Michael, et al.
Publicado: (2012)

Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire
por: Gray, Daniel, et al.
Publicado: (2007)

Impact of Diabetes Susceptibility Loci on Progression From Pre-Diabetes to Diabetes in At-Risk Individuals of the Diabetes Prevention Trial–Type 1 (DPT-1)
por: Butty, Vincent, et al.
Publicado: (2008)

Physiological β Cell Death Triggers Priming of Self-reactive T Cells by Dendritic Cells in a Type-1 Diabetes Model
por: Turley, Shannon, et al.
Publicado: (2003)

Suppressive IL-17A(+)Foxp3(+) and ex-Th17 IL-17A(neg)Foxp3(+) T(reg) cells are a source of tumour-associated T(reg) cells
por: Downs-Canner, Stephanie, et al.
Publicado: (2017)

The mark of T reg cells
por: Van Epps, Heather L.
Publicado: (2005)

Persistence of Peptide-induced CD4(+) T cell Anergy In Vitro
por: Ryan, Kelli R., et al.
Publicado: (1998)

Loss of the proapoptotic protein, Bim, breaks B cell anergy
por: Oliver, Paula M., et al.
Publicado: (2006)

Recombinant Reg3α Prevents Islet β-Cell Apoptosis and Promotes β-Cell Regeneration
por: Yu, Luting, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_5hc8f6sgh4flvlhgasrhosdbbp