Molecular Basis for poly(A) RNP Architecture and Recognition by the Pan2-Pan3 Deadenylase

The stability of eukaryotic mRNAs is dependent on a ribonucleoprotein (RNP) complex of poly(A)-binding proteins (PABPC1/Pab1) organized on the poly(A) tail. This poly(A) RNP not only protects mRNAs from premature degradation but also stimulates the Pan2-Pan3 deadenylase complex to catalyze the first...

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Detalles Bibliográficos
Autores principales: Schäfer, Ingmar B., Yamashita, Masami, Schuller, Jan Michael, Schüssler, Steffen, Reichelt, Peter, Strauss, Mike, Conti, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547884/
https://www.ncbi.nlm.nih.gov/pubmed/31104843
http://dx.doi.org/10.1016/j.cell.2019.04.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547884/
https://www.ncbi.nlm.nih.gov/pubmed/31104843
http://dx.doi.org/10.1016/j.cell.2019.04.013

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