A balancing act: PHLPP2 fine tunes AKT activity and MYC stability in prostate cancer

PTEN loss stimulates prostate tumor progression by sustaining AKT activation. Nowak et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902048) surprisingly show that the AKT-suppressing phosphatase PHLPP2 promotes disease progression in the context of dual PTEN and p53 loss by increasing MYC...

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Detalles Bibliográficos
Autores principales: Toivanen, Roxanne, Furic, Luc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548122/
https://www.ncbi.nlm.nih.gov/pubmed/31145683
http://dx.doi.org/10.1083/jcb.201904119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548122/
https://www.ncbi.nlm.nih.gov/pubmed/31145683
http://dx.doi.org/10.1083/jcb.201904119

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