A balancing act: PHLPP2 fine tunes AKT activity and MYC stability in prostate cancer

PTEN loss stimulates prostate tumor progression by sustaining AKT activation. Nowak et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902048) surprisingly show that the AKT-suppressing phosphatase PHLPP2 promotes disease progression in the context of dual PTEN and p53 loss by increasing MYC...

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Detalles Bibliográficos
Autores principales: Toivanen, Roxanne, Furic, Luc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548122/
https://www.ncbi.nlm.nih.gov/pubmed/31145683
http://dx.doi.org/10.1083/jcb.201904119
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author Toivanen, Roxanne
Furic, Luc
author_facet Toivanen, Roxanne
Furic, Luc
author_sort Toivanen, Roxanne
collection PubMed
description PTEN loss stimulates prostate tumor progression by sustaining AKT activation. Nowak et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902048) surprisingly show that the AKT-suppressing phosphatase PHLPP2 promotes disease progression in the context of dual PTEN and p53 loss by increasing MYC stability.
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spelling pubmed-65481222019-12-28 A balancing act: PHLPP2 fine tunes AKT activity and MYC stability in prostate cancer Toivanen, Roxanne Furic, Luc J Cell Biol Commentaries PTEN loss stimulates prostate tumor progression by sustaining AKT activation. Nowak et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902048) surprisingly show that the AKT-suppressing phosphatase PHLPP2 promotes disease progression in the context of dual PTEN and p53 loss by increasing MYC stability. Rockefeller University Press 2019-06-28 2019-05-15 /pmc/articles/PMC6548122/ /pubmed/31145683 http://dx.doi.org/10.1083/jcb.201904119 Text en © 2019 Toivanen and Furic http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentaries
Toivanen, Roxanne
Furic, Luc
A balancing act: PHLPP2 fine tunes AKT activity and MYC stability in prostate cancer
title A balancing act: PHLPP2 fine tunes AKT activity and MYC stability in prostate cancer
title_full A balancing act: PHLPP2 fine tunes AKT activity and MYC stability in prostate cancer
title_fullStr A balancing act: PHLPP2 fine tunes AKT activity and MYC stability in prostate cancer
title_full_unstemmed A balancing act: PHLPP2 fine tunes AKT activity and MYC stability in prostate cancer
title_short A balancing act: PHLPP2 fine tunes AKT activity and MYC stability in prostate cancer
title_sort balancing act: phlpp2 fine tunes akt activity and myc stability in prostate cancer
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548122/
https://www.ncbi.nlm.nih.gov/pubmed/31145683
http://dx.doi.org/10.1083/jcb.201904119
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