PAK2 links cell survival to mechanotransduction and metabolism

Too little or too much force can trigger cell death, yet factors that ensure the survival of cells remain largely unknown. Here, we demonstrate that E-cadherin responds to force by recruiting and activating p21-activated protein kinase 2 (PAK2) to allow cells to stiffen, metabolize, and survive. Int...

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Detalles Bibliográficos
Autores principales: Campbell, Hannah K., Salvi, Alicia M., O’Brien, Timothy, Superfine, Richard, DeMali, Kris A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548143/
https://www.ncbi.nlm.nih.gov/pubmed/30940647
http://dx.doi.org/10.1083/jcb.201807152

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548143/
https://www.ncbi.nlm.nih.gov/pubmed/30940647
http://dx.doi.org/10.1083/jcb.201807152

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