Cargando…

Cytochalasin H Inhibits Angiogenesis via the Suppression of HIF-1α Protein Accumulation and VEGF Expression through PI3K/AKT/P70S6K and ERK1/2 Signaling Pathways in Non-Small Cell Lung Cancer Cells

Our previous study has demonstrated that cytochalasin H (CyH) isolated from mangrove-derived endophytic fungus induces apoptosis and inhibits migration in A549 non-small cell lung cancer (NSCLC) cells. In this study, we further explored the effect of CyH on angiogenesis in NSCLC cells and the underl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ma, Yuefan, Xiu, Zihan, Zhou, Zhiyuan, Huang, Bingyu, Liu, Jiao, Wu, Xiaofeng, Li, Sanzhong, Tang, Xudong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548170/ https://www.ncbi.nlm.nih.gov/pubmed/31205560 http://dx.doi.org/10.7150/jca.29933

Ejemplares similares

Cytochalasin H Inhibits Angiogenesis via the Suppression of HIF-1α Protein Accumulation and VEGF Expression through PI3K/AKT/P70S6K and ERK1/2 Signaling Pathways in Non-Small Cell Lung Cancer Cells: Erratum
por: Ma, Yuefan, et al.
Publicado: (2023)

PI3K/Akt/HIF-1α signaling pathway mediates HPV-16 oncoprotein-induced expression of EMT-related transcription factors in non-small cell lung cancer cells
por: Liu, Jinhua, et al.
Publicado: (2018)

PI3K/Akt/HIF-1α signaling pathway mediates HPV-16 oncoprotein-induced expression of EMT-related transcription factors in non-small cell lung cancer cells: Erratum
por: Liu, Jinhua, et al.
Publicado: (2023)

Cytochalasin H isolated from mangrove-derived endophytic fungus inhibits epithelial-mesenchymal transition and cancer stemness via YAP/TAZ signaling pathway in non-small cell lung cancer cells
por: Xiu, Zihan, et al.
Publicado: (2021)

Cytochalasin H isolated from mangrove-derived endophytic fungus inhibits epithelial-mesenchymal transition and cancer stemness via YAP/TAZ signaling pathway in non-small cell lung cancer cells: Erratum
por: Xiu, Zihan, et al.
Publicado: (2023)

Melittin Suppresses HIF-1α/VEGF Expression through Inhibition of ERK and mTOR/p70S6K Pathway in Human Cervical Carcinoma Cells
por: Shin, Jae-Moon, et al.
Publicado: (2013)

Downregulation of VEGFR2 signaling by cedrol abrogates VEGF‑driven angiogenesis and proliferation of glioblastoma cells through AKT/P70S6K and MAPK/ERK1/2 pathways
por: Chang, Kai-Fu, et al.
Publicado: (2023)

Arnebin-1 promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway
por: ZENG, ZHI, et al.
Publicado: (2015)

Arnebin-1 promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway
por: Zeng, Zhi, et al.
Publicado: (2023)

Regulation of Osteogenesis-Angiogenesis Coupling by HIFs and VEGF
por: Schipani, Ernestina, et al.
Publicado: (2009)

Saikosaponin b2 inhibits tumor angiogenesis in liver cancer via down‑regulation of VEGF/ERK/HIF‑1α signaling
por: You, Man, et al.
Publicado: (2023)

C-reactive protein can upregulate VEGF expression to promote ADSC-induced angiogenesis by activating HIF-1α via CD64/PI3k/Akt and MAPK/ERK signaling pathways
por: Chen, JiaYuan, et al.
Publicado: (2016)

Differential expression of angiogenesis markers HSP70, HSP90, VEGF and pERK1/2 in both components of dedifferentiated chondrosarcomas
por: Schoedel, Karen, et al.
Publicado: (2021)

Aloe-emodin suppresses hypoxia-induced retinal angiogenesis via inhibition of HIF-1α/VEGF pathway
por: Wu, Jianming, et al.
Publicado: (2016)

ERK Signaling Pathway Is Involved in HPV-16 E6 but not E7 Oncoprotein-Induced HIF-1α Protein Accumulation in NSCLC Cells
por: Liu, Fei, et al.
Publicado: (2016)

Roles of PI3K/Akt and c-Jun Signaling Pathways in Human Papillomavirus Type 16 Oncoprotein-Induced HIF-1α, VEGF, and IL-8 Expression and In Vitro Angiogenesis in Non-Small Cell Lung Cancer Cells
por: Zhang, Erying, et al.
Publicado: (2014)

Melatonin restricts the viability and angiogenesis of vascular endothelial cells by suppressing HIF-1α/ROS/VEGF
por: Cheng, Jiao, et al.
Publicado: (2019)

Erianin inhibits high glucose-induced retinal angiogenesis via blocking ERK1/2-regulated HIF-1α-VEGF/VEGFR2 signaling pathway
por: Yu, Zengyang, et al.
Publicado: (2016)

Overexpression of Human Papillomavirus Type 16 Oncoproteins Enhances Epithelial–Mesenchymal Transition via STAT3 Signaling Pathway in Non-Small Cell Lung Cancer Cells
por: Zhang, Wenzhang, et al.
Publicado: (2017)

Adiponectin promotes VEGF-A-dependent angiogenesis in human chondrosarcoma through PI3K, Akt, mTOR, and HIF-α pathway
por: Lee, Hsiang-Ping, et al.
Publicado: (2015)

Association of Dll4/Notch and HIF-1a -VEGF Signaling in the Angiogenesis of Missed Abortion
por: Fang, Yan, et al.
Publicado: (2013)

Tanshinone IIA Inhibits HIF-1α and VEGF Expression in Breast Cancer Cells via mTOR/p70S6K/RPS6/4E-BP1 Signaling Pathway
por: Li, Guobing, et al.
Publicado: (2015)

CCL19 suppresses angiogenesis through promoting miR-206 and inhibiting Met/ERK/Elk-1/HIF-1α/VEGF-A pathway in colorectal cancer
por: Xu, Zhuoqing, et al.
Publicado: (2018)

Nuclear factor 90 promotes angiogenesis by regulating HIF-1α/VEGF-A expression through the PI3K/Akt signaling pathway in human cervical cancer
por: Zhang, Wenqian, et al.
Publicado: (2018)

MiR-128 Inhibits Tumor Growth and Angiogenesis by Targeting p70S6K1
por: Shi, Zhu-mei, et al.
Publicado: (2012)

NADPH Oxidase 4 Mediates Insulin-Stimulated HIF-1α and VEGF Expression, and Angiogenesis In Vitro
por: Meng, Dan, et al.
Publicado: (2012)

Early missed abortion is associated with villous angiogenesis via the HIF-1α/VEGF signaling pathway
por: Zhi, Zhifu, et al.
Publicado: (2018)

Novel Nargenicin A1 Analog Inhibits Angiogenesis by Downregulating the Endothelial VEGF/VEGFR2 Signaling and Tumoral HIF-1α/VEGF Pathway
por: Han, Jang Mi, et al.
Publicado: (2020)

20(S)-Protopanaxadiol enhances angiogenesis via HIF-1α-mediated VEGF secretion by activating p70S6 kinase and benefits wound healing in genetically diabetic mice
por: Zhang, Er-Yun, et al.
Publicado: (2017)

Houshiheisan promotes angiogenesis via HIF-1α/VEGF and SDF-1/CXCR4 pathways: in vivo and in vitro
por: Xiang, Yangyang, et al.
Publicado: (2019)

Chronic cocaine induces HIF-VEGF pathway activation along with angiogenesis in the brain
por: Yin, Wei, et al.
Publicado: (2017)

Ginsenoside Rg1 Nanoparticles Induce Demethylation of H3K27me3 in VEGF-A and Jagged 1 Promoter Regions to Activate Angiogenesis After Ischemic Stroke
por: Shang, Wei, et al.
Publicado: (2022)

CD133 mediates the TGF-β1-induced activation of the PI3K/ERK/P70S6K signaling pathway in gastric cancer cells
por: Zhu, Youlong, et al.
Publicado: (2017)

HIF-1α increases the osteogenic capacity of ADSCs by coupling angiogenesis and osteogenesis via the HIF-1α/VEGF/AKT/mTOR signaling pathway
por: Song, Shuang, et al.
Publicado: (2023)

MiR-21 Induced Angiogenesis through AKT and ERK Activation and HIF-1α Expression
por: Liu, Ling-Zhi, et al.
Publicado: (2011)

Human umbilical cord mesenchymal stem cell promotes angiogenesis via integrin β1/ERK1/2/HIF-1α/VEGF-A signaling pathway for off-the-shelf breast tissue engineering
por: Wu, Mian, et al.
Publicado: (2022)

ADAMTS-1 inhibits angiogenesis via the PI3K/Akt-eNOS-VEGF pathway in lung cancer cells
por: Wang, Bu, et al.
Publicado: (2019)

Kaempferol Inhibits Angiogenesis by Suppressing HIF-1α and VEGFR2 Activation via ERK/p38 MAPK and PI3K/Akt/mTOR Signaling Pathways in Endothelial Cells
por: Kim, Gi Dae
Publicado: (2017)

Dandelion Polysaccharide Exerts Anti-Angiogenesis Effect on Hepatocellular Carcinoma by Regulating VEGF/HIF-1α Expression
por: Ren, Feng, et al.
Publicado: (2020)

Safranal Inhibits Angiogenesis via Targeting HIF-1α/VEGF Machinery: In Vitro and Ex Vivo Insights
por: Abdalla, Ali, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_rl6q5amd9fgi3iccsh5g5ec8er