Cargando…

Recognition and stabilization of geranylgeranylated human Rab5 by the GDP Dissociation Inhibitor (GDI)

The small GTPase Rab5 is the key regulator of early endosomal fusion. It is post-translationally modified by covalent attachment of two geranylgeranyl (GG) chains to adjacent cysteine residues of the C-terminal hypervariable region (HVR). The GDP dissociation inhibitor (GDI) recognizes membrane-asso...

Descripción completa

Detalles Bibliográficos
Autores principales:	Edler, Eileen, Stein, Matthias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2017
Materias:	Research Paper/Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548291/ https://www.ncbi.nlm.nih.gov/pubmed/29065764 http://dx.doi.org/10.1080/21541248.2017.1371268

Ejemplares similares

Targeting GDP-Dissociation Inhibitor Beta (GDI2) with a Benzo[a]quinolizidine Library to Induce Paraptosis for Cancer Therapy
por: Sun, Yong, et al.
Publicado: (2023)

Phosphonocarboxylates Inhibit the Second Geranylgeranyl Addition by Rab Geranylgeranyl Transferase
por: Baron, Rudi A., et al.
Publicado: (2009)

Rab-GDI Complex Dissociation Factor Expressed through Translational Frameshifting in Filamentous Ascomycetes
por: Malagnac, Fabienne, et al.
Publicado: (2013)

Searching for Signaling Balance through the Identification of Genetic Interactors of the Rab Guanine-Nucleotide Dissociation Inhibitor gdi-1
por: Lee, Anna Y., et al.
Publicado: (2010)

Probing the druggability of membrane-bound Rab5 by molecular dynamics simulations
por: Edler, Eileen, et al.
Publicado: (2017)

Molecular control of Rab activity by GEFs, GAPs and GDI
por: Müller, Matthias P., et al.
Publicado: (2017)

Bioinformatics analysis of Rab GDP dissociation inhibitor beta and its expression in non-small cell lung cancer
por: Ming, Zongjuan, et al.
Publicado: (2014)

Rational design, optimization, and biological evaluation of novel α-Phosphonopropionic acids as covalent inhibitors of Rab geranylgeranyl transferase
por: Małolepsza, Joanna, et al.
Publicado: (2022)

Rab geranylgeranyl transferase β subunit is essential for male fertility and tip growth in Arabidopsis
por: Gutkowska, Malgorzata, et al.
Publicado: (2015)

Protective Role of Rho Guanosine Diphosphate Dissociation Inhibitor, Ly-GDI, in Pulmonary Alveolitis
por: Yan, Chunguang, et al.
Publicado: (2015)

The cytoplasmic domain of chondrolectin interacts with the β-subunit of rab geranylgeranyl transferase
por: Claessens, An, et al.
Publicado: (2008)

Overexpression of GDP dissociation inhibitor 1 gene associates with the invasiveness and poor outcomes of colorectal cancer
por: Xie, Xiao, et al.
Publicado: (2021)

Single GDP-dissociation Inhibitor Protein regulates endocytic and secretory pathways in Leishmania
por: Shanmugam, Senthil kumar, et al.
Publicado: (2016)

eIF2β is critical for eIF5-mediated GDP-dissociation inhibitor activity and translational control
por: Jennings, Martin D., et al.
Publicado: (2016)

The Rab Geranylgeranyl Transferase Beta Subunit Is Essential for Embryo and Seed Development in Arabidopsis thaliana
por: Rojek, Joanna, et al.
Publicado: (2021)

GDI-1 preferably interacts with Rab10 in insulin-stimulated GLUT4 translocation
por: Chen, Yu, et al.
Publicado: (2009)

RabGDI controls axonal midline crossing by regulating Robo1 surface expression
por: Philipp, Melanie, et al.
Publicado: (2012)

Regulation of cytoplasmic division of Xenopus embryo by rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI)
Publicado: (1993)

Tamarindus indica Extract Alters Release of Alpha Enolase, Apolipoprotein A-I, Transthyretin and Rab GDP Dissociation Inhibitor Beta from HepG2 Cells
por: Chong, Ursula Rho Wan, et al.
Publicado: (2012)

Geranylgeranylated Snares Are Dominant Inhibitors of Membrane Fusion
por: Grote, Eric, et al.
Publicado: (2000)

Molecular and functional characterization of a Rho GDP dissociation inhibitor in the filamentous fungus Tuber borchii
por: Menotta, Michele, et al.
Publicado: (2008)

A Rho GDP Dissociation Inhibitor Produced by Apoptotic T-Cells Inhibits Growth of Mycobacterium tuberculosis
por: Venkatasubramanian, Sambasivan, et al.
Publicado: (2015)

Differential requirements of protein geranylgeranylation for the virulence of human pathogenic fungi
por: Souza, Ana Camila Oliveira, et al.
Publicado: (2019)

Structure and Dynamics of Mono- vs. Doubly Lipidated Rab5 in Membranes
por: Münzberg, Eileen, et al.
Publicado: (2019)

Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors
por: Yoshimura, Shin-ichiro, et al.
Publicado: (2010)

The Fer tyrosine kinase regulates interactions of Rho GDP-Dissociation Inhibitor α with the small GTPase Rac
por: Fei, Fei, et al.
Publicado: (2010)

eIF2B promotes eIF5 dissociation from eIF2•GDP to facilitate guanine nucleotide exchange for translation initiation
por: Jennings, Martin D., et al.
Publicado: (2013)

Synthesis of the 6-Substituted Imidazo[1,2-a]Pyridine-3-yl-2- Phosphonopropionic Acids as Potential Inhibitors of Rab Geranylgeranyl Transferase
por: Kusy, Damian, et al.
Publicado: (2021)

Graphics programming with GDI
por: Chand, Mahesh
Publicado: (2004)

Placenta-specific novel splice variants of Rho GDP dissociation inhibitor β are highly expressed in cancerous cells
por: Hatakeyama, Keiichi, et al.
Publicado: (2012)

Rho GDP‐dissociation inhibitor α is a potential prognostic biomarker and controls telomere regulation in colorectal cancer
por: Huang, Dandan, et al.
Publicado: (2017)

Developmental Upregulation of an Alternative Form of pcp2 with Reduced GDI Activity
por: Barski, Jaroslaw J., et al.
Publicado: (2013)

Recent Advances in the Development of Mammalian Geranylgeranyl Diphosphate Synthase Inhibitors
por: Haney, Staci L., et al.
Publicado: (2017)

A helitron-induced RabGDIα variant causes quantitative recessive resistance to maize rough dwarf disease
por: Liu, Qingcai, et al.
Publicado: (2020)

Geranylgeranyl diphosphate synthase inhibitor and proteasome inhibitor combination therapy in multiple myeloma
por: Haney, Staci L., et al.
Publicado: (2022)

FERM Domain Containing Protein 7 Interacts with the Rho GDP Dissociation Inhibitor and Specifically Activates Rac1 Signaling
por: Pu, Jiali, et al.
Publicado: (2013)

Reduced expression of Rho GDP dissociation inhibitor 2 mRNA is associated with lymph node metastasis in gastric carcinoma
por: SHIDA, ATSUO, et al.
Publicado: (2013)

Effects of mevalonate kinase interference on cell differentiation, apoptosis, prenylation and geranylgeranylation of human keratinocytes are attenuated by farnesyl pyrophosphate or geranylgeranyl pyrophosphate
por: Li, Min, et al.
Publicado: (2020)

A quantitative method to measure geranylgeranyl diphosphate (GGPP) and geranylgeranyl monophosphate (GGP) in tomato (Solanum lycopersicum) fruit
por: Zita, Wayne, et al.
Publicado: (2023)

GDI2 is a novel diagnostic and prognostic biomarker in hepatocellular carcinoma
por: Zhang, Wen, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_e8ggs74vfd9mk6rn9m391satjl