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Noise-precision tradeoff in predicting combinations of mutations and drugs

Many biological problems involve the response to multiple perturbations. Examples include response to combinations of many drugs, and the effects of combinations of many mutations. Such problems have an exponentially large space of combinations, which makes it infeasible to cover the entire space ex...

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Detalles Bibliográficos
Autores principales: Tendler, Avichai, Zimmer, Anat, Mayo, Avi, Alon, Uri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548401/
https://www.ncbi.nlm.nih.gov/pubmed/31116755
http://dx.doi.org/10.1371/journal.pcbi.1006956